Abstract :Pediatric dentists have an important role in the care and maintenance of oral health for children with Autism Spectrum Disorder (ASD). The primary goals of dental care are to maximize oral health and function, and to help facilitate understanding of the primary features of ASD with families and other medical and dental providers. To assist oral health professionals in the understanding of autism and associated comorbidities, this report reviews the medical presentation of patients with autism and implications for dentistry. We describe the physiological, behavioral, sensory and gastrointestinal considerations of ASD, as well as associated medical conditions, pharmacologic and non pharmacological behavior guidance, and dental considerations for the management of patients with autism. Optimization of oral health is more likely when providers understand the context of patients who present with autism and are able to educate families, guiding them toward effective interventions for health.